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Internship Project: AI-Driven Variant Prioritization for Clinical Genomics

Complete an internship project at SOPHiA GENETICS whose mission is to build the future of AI-assisted medicine. Joining the Data Science team as a Junior Bioinformatician Intern.

Your Mission:

Reporting to the Head of Tertiary Analysis Research team, you will explore how state-of-the-art AI algorithms can enable faster, easier and more accurate variant prioritization and interpretation during the tertiary analysis step of the genetic testing workflow. Variant prioritization and interpretation steps are at the interface between bioinformatics pipelines and clinical interpretation of the patient data – this creates a unique and exciting opportunity to bridge cutting-edge computational methods with real-world clinical impact.

You will be involved in:

• Learning and understanding main principles and current challenges in tertiary analysis.
• Evaluating use of different AI models to address those challenges.
• Creating a prototype workflow that aims to address a selected task in tertiary analysis workflow.
• Benchmarking, evaluating and reporting the analytical and technical performance of the prototype.

What you will learn:

- Knowledge:

• Understanding of the role of tertiary analysis in genetic testing.
• Clinical databases content and structure used in genetic diagnostics.

- Technical Skills:

• State-of-the-art tools and statistical algorithms for variant interpretation at both research- and industry-level of use.
• Reproducible benchmarking.
• The process of research and development in the industry setting.
• General concepts of design controls for software as medical device development.

- Industry setting experience:

• Working within an international and interdisciplinary team.
• Working in a transversal team collaborating across multiple teams and departments.

Requirements

The experience you bring:

• Understanding of machine learning and statistical inference methods.
• Basic knowledge of bioinformatics methods used in the field of genetics.
• Understanding of concepts and mechanisms of clinical genetics.
• Competence with programming languages (Python or R).
• Degree in Bioinformatics, Computational Biology, Genetics, Genomics.
• Full Proficiency in English

Benefits

You will be joining an organization with the patient at the heart of every decision and action, driven by purpose as we pursue exponential growth.

Business recognition and accolades include:

• World's most innovative companies (Top 10)
• World's smartest companies (Top 50)
• 100 Best Places to Work in Boston
• Top 10 European Tech Startup
• Top 10 European biotechs startup to watch
• Top 25 East-Coast Biotech to watch

Our benefits package is comprehensive, but varies internationally in-line with local standards and laws. You can discuss a full breakdown with us, but as a brief overview:

• A fun and engaging work environment, with Rest & Entertainment space, full stocked free coffee machine and free fruit/snacks
• Free parking in an easy to access location
• A strong social committee whose purpose is to make SOPHiA GENETICs both enjoyable as well as rewarding
• As our global HQ, you’ll have direct interaction and exposure to senior leadership and our executive team locally

Our DNA

Like the strands of DNA itself, SOPHiA GENETICS and the team are deeply interconnected and reliant on each other to deliver. There are common threads across the team. Things that bind us together. Those things are Relentless Curious; Resilient & Nimble and Fearlessly Adventurous

Our Virtues

At SOPHiA GENETICS we established our 7 Virtues to clarify how our principles show up each day through action. We Decide; We Do; We Collaborate; We Innovate; We Empower; We Adapt and We Learn.

At the centre of our Virtues is our Mantra, We Care, which provides a constant reminder of the compassionate, benevolent, and hopeful nature of our mission and how it should be threaded through each of our Virtues and everything we do. Learn more about our DNA and Virtues on our Careers portal

The Process

Apply now with your CV and any supporting information.

Suitably qualified candidates will be invited through an interview and screening process where you will speak with members of our Talent Acquisition Team, the hiring leader alongside key colleagues and stakeholders from across the business. If you need additional support for accessibility, please contact our TA team for assistance.

We appreciate the value external partners can bring, but we operate a direct-hiring model and we are not looking to utilize agency support at this time. All hiring is controlled by Talent Acquisition, potential partners should liaise through TA and not our hiring teams please.

Starting Date: April 2026

Location: Rolle, CH

Contract: Internship contract, 6 months - Full time