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At HAYA Therapeutics, we are revolutionizing RNA-guided genome-targeting therapies to treat fibrosis, heart failure, and other serious diseases associated with aging. Our innovative platform leverages long non-coding RNAs (lncRNAs)—key regulators within the “dark matter” of the genome—to develop first-in-class, highly specific therapies that modulate gene expression and restore cellular function.

Recognized for our innovation, HAYA received the prestigious Innosuisse Certificate for Sustainable Growth and has been nominated as TOP Innovative Companies in Switzerland 2025. As a fast-growing biotech, we offer an entrepreneurial, science-driven environment where you’ll have a direct impact on shaping our pipeline and advancing RNA medicine.

Purpose:

The Clinical Program Manager acts as a central contact for information on a particular program and enables the seamless transition and execution of clinical development programs from DC nomination through clinical phases to ensure the timely, budget-compliant, and high-quality delivery of therapeutic assets.

Accountabilities

• Lead cross-functional program activities and communications across clinical, nonclinical, biomarkers, CMC, regulatory, and quality departments to ensure the synchronized progression and delivery of clinical development programs.
• Consolidate integrated program timelines and operational plans across all contributing disciplines to proactively resolve bottlenecks and maintain on-target execution of key milestones.
• Coordinate critical supply schedules and data deliverables from CMC and nonclinical teams to guarantee the timely availability of clinical trial materials and supporting safety profiles for active studies.
• Integrate strategic guidance and documentation reviews from regulatory and quality assurance functions to maintain strict compliance with global health authority standards throughout the development lifecycle.
• Manage program scope, monthly forecasts, and financial changes through active variance tracking to ensure strict adherence to overall clinical trial budgets.
• Maintain comprehensive program information and the actions, decisions, and risks (ADR) log to facilitate proactive mitigation strategies, resolve escalating issues, and ensure accurate visibility for senior leadership.

Requirements

Required Knowledge and Experience

• Clinical Development & Regulatory Expertise: Proven technical proficiency in guiding early-stage therapeutic assets through Investigational New Drug (IND) transitions into active clinical development, supported by a thorough understanding of each functional area’s role and contribution to the development process
• Operational Planning & Execution: Demonstrated capability in clinical program management, with in-depth knowledge of developing integrated global drug development plans, executing timeline remediation, and proactively resolving cross-functional bottlenecks.
• Financial & Vendor Management: Functional expertise in strategic budget assessment, monthly financial forecasting, variance tracking, and monitoring complex clinical trial budgets and CRO milestones.
• Risk Mitigation & Documentation: Capability in analytical problem-solving and maintaining robust program documentation, specifically actions, decisions, and risks (ADR) logs, to drive proactive mitigation strategies and ensure data visibility for leadership.
• Communication & Systems Proficiency: Excellent interpersonal, communication, and negotiation skills essential for aligning cross-functional teams, coupled with solid technical proficiency in MS Project, Excel, PowerPoint, and Outlook.

Leadership Profile

The successful candidate will demonstrate:

• Exceptional analytical acumen focused on delivering accurate, comprehensive data reporting to global organizational stakeholders.
• Proactive risk-management capabilities, consistently identifying and escalating critical timeline or budget issues without compromising program integrity.
• Strong collaborative leadership, seamlessly aligning cross-functional teams toward the unified execution of strategic clinical goals.

HAYA Therapeutics is an Equal Opportunity Employer committed to fostering a diverse, inclusive, and equitable workplace where all individuals feel valued and empowered. We provide equal employment opportunities to all qualified applicants and employees without regard to race, color, religion, sex (including pregnancy, sexual orientation, gender identity, or gender expression), national origin, ancestry, age, marital or familial status, veteran status, disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws.

We prohibit discrimination and harassment of any kind and are committed to ensuring fair and equitable treatment in all aspects of recruitment, hiring, promotion, compensation, benefits, training, and career development.

At HAYA, we believe that diversity of thought, experience, and background drives innovation and strengthens our mission to transform patient care through cutting-edge RNA-based therapeutics.

Notice to Recruitment Agencies & Search Firms:

HAYA Therapeutics operates a Preferred Supplier List (PSL) and manages all recruitment directly through our Human Resources team. We do not accept unsolicited resumes or speculative CVs from third-party agencies, search firms, or recruiters. Any unsolicited candidates or CVs submitted through non-approved channels, directly to HAYA employees, or without a fully executed recruitment agreement in place will be considered property of HAYA Therapeutics. HAYA Therapeutics will not pay any fee, liability, or finder's fee for candidates submitted under these circumstances.