At Roche you can show up as yourself embraced for the unique qualities you bring. Our culture encourages personal expression open dialogue and genuine connections where you are valued accepted and respected for who you are allowing you to thrive both personally and professionally. This is how we aim to prevent stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche where every voice matters.
The Position
In Roches Pharmaceutical Research and Early Development organisation (pRED) we make transformative medicines for patients to tackle some of the worlds toughest unmet healthcare needs. At pRED we are united by our mission to transform science into medicines. Together we create a culture defined by curiosity responsibility and humility where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
At the intersection of science and innovation pREDs Pharmaceutical Sciences (PS) organisation enables the discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation continuously improve the accuracy of our predictions and accelerate the development of tomorrows medicines. By seamlessly integrating our three core pillarsTranslational Safety Translational Pharmacology and Biomarkers - we drive end-to-end asset development across the entire value chain from target assessment to on-market support. Our mission is to continuously improve predictive accuracy optimise dosing strategies for the right patient populations and accelerate the development of tomorrows safe and effective therapeutics.
This position is located in Pathology and Applied Safety Science a department within the Pharmaceutical Sciences function. We drive the non-clinical safety assessment of drug candidates from small molecules to complex biological products during the discovery and development phases at Roche.
The Opportunity
- In Vivo - in vitro Immunosafety Integration & Mechanistic Strategy: Formulate implement and champion integrated immunosafety strategies for portfolio projects ensuring the scientific validation and execution of predictive immunological biomarkers. Interrogate and decode in vivo immunosafety findings (e.g. changes in lymphoid architecture immunogenicity readouts cytokine profiles or systemic hypersensitivities) and connect them back to mechanistic context using investigative in vitro tools. Translate complex immunological findings into unified safety position documentation presenting definitive impact summaries for target validation compound profiling and IND/CTA-enabling packages.
- Advancing In Vitro Cellular Models via Immunological Elements: Proactively apply human immunology elements (e.g. primary immune cells immune-epithelial co-cultures inflammatory stimulus circuits) to upgrade the physiological accuracy of predictive in vitro cell models. Pioneer the optimisation validation and scale of 2D 3D and fluidic microphysiological safety systems ensuring that models capture intricate human-specific responses like cytokine release syndromes immune-mediated organ toxicities or structural hypersensitivities. Drive proficiency in state-of-the-art analytical platforms such as high-content screening flow cytometry multiplexed fluid assays and spatial or transcriptomic single-cell readouts.
- Proactive Data Curation Reporting & LIMS Operations: Conduct rigorous data analysis critical validation of assays and proper internal reporting of study phase data within the Laboratory Information Management System (LIMS). Act as the lead presenter of immunotoxicology assessments translating highly specialised immune data into actionable easy-to-digest go/no-go recommendations for project toxicologists and multi-disciplinary teams. Ensure impeccable documentation maintain pristine raw data storage folders and strictly fulfil international compliance archiving requirements.
- Quality Compliance and Laboratory Standards: Oversee and evaluate study data compliance under existing work instructions Standard Operating Procedures (SOPs) and strict safety regulations logging experimental deviations comprehensively. Comply with Safety Health and Environmental (SHE) regulations championing mindful handling storage and ethical processing of materials from animal or human origins.
- Multi-Disciplinary Collaboration & Initiative: Serve as a collaborative scientific anchor across pathobiology wet-lab toxicologists and clinical safety to break down functional silos and rapidly resolve complex safety anomalies. Act with foresight and urgency to proactively design and execute targeted investigative protocols that address emerging portfolio liabilities before they impact project milestones. Consistently engage with internal peers chapter lines and stakeholders to efficiently prioritise and align laboratory resource flows under demanding schedules.
- Continuous Process Optimisation & Vendor Engagement: Drive an agile laboratory mindset focused on process optimisation to permanently elevate assay reproducibility automate computational imaging inputs and shorten compound turnaround times. Establish and sustain strategic relationships with external technology providers Contract Research Organisations (CROs) and international scientific bodies to continuously benchmark and onboard next-generation immunotoxicology concepts.
Who you are
- You hold a PhD degree in an immunology-related field with a strong industry focus on in vitro and/or in vivo human immunology or immunotoxicology assessment.
- You bring demonstrated experience formulating integrated immunosafety strategies and upgrading predictive cell models (including 2D 3D and fluidic microphysiological systems) using state-of-the-art analytical platforms like flow cytometry and high-content screening.
- You possess strong proficiency in data curation critical assay validation and LIMS reporting with a proven ability to translate complex data into unified safety position documentation actionable go/no-go recommendations and IND/CTA-enabling packages.
- You demonstrate exceptional interpersonal skills and matrix flexibility acting as a trusted scientific anchor who connects global teams optimises laboratory processes for efficiency and embraces entrepreneurial thinking under the Roche Leadership Framework (Creative Mindset VACC).
At Roche we aim high to deliver life-changing healthcare solutions. If youre ready to make a meaningful impact on patients and healthcare systems worldwide this is the place for you.
Who we are
A healthier future drives us to innovate. Together more than 100000 employees across the globe are dedicated to advance science ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities foster creativity and keep our ambitions high so we can deliver life-changing healthcare solutions that make a global impact.
Lets build a healthier future together.
Roche is an Equal Opportunity Employer.
Required Experience:
IC
Employment Type : Full-Time
Experience: years
Vacancy: 1
