Talent.com
Research Associate, Computational Ion Channel Design, Synthetic and Structural Biology 100%
Research Associate, Computational Ion Channel Design, Synthetic and Structural Biology 100%The Biozentrum, University of Basel • Basel, CH
Les candidatures ne sont plus acceptées
Research Associate, Computational Ion Channel Design, Synthetic and Structural Biology 100%

Research Associate, Computational Ion Channel Design, Synthetic and Structural Biology 100%

The Biozentrum, University of Basel • Basel, CH
Il y a plus de 30 jours
Description de poste

Your position

  • Own the computational and structural design cycle for ion channels and light-sensitive membrane proteins (concept - design hypotheses - in silico screening - selection of candidates for testing), in close interaction with experimental and translational collaborators.
  • Define clear design objectives and success criteria and translate designs into practical construct and assay plans.
  • Develop and apply learned-model–assisted protein design workflows (structure prediction, inverse folding/sequence design, sequence scoring, and generative proposal methods) and integrate them with experimental feedback across iterative design cycles.
  • Execute a targeted experimental validation workflow (limited hands-on bench work): some routine mammalian cell culture, DNA cloning/construct handling as needed, transfection/transduction, and small-scale expression testing in HEK/CHO (or equivalent).
  • Coordinate and interpret functional readouts generated with the team (e.g., electrophysiology, imaging, biochemical assays), using results to iterate designs.
  • Communicate progress and results clearly in internal updates, written documentation, and project meetings; contribute to conference presentations and manuscripts as appropriate.
  • Maintain accurate records and effective day-to-day communication with your supervisor and collaborators.

Your profile

  • PhD (or equivalent experience) in computational biology, protein engineering, structural biology, biophysics, biochemistry, molecular/cell biology, or a closely related field.
  • ≥3 years of post-graduate (or equivalent) experience with at least two of the following:
  • computational/structure-based protein design (especially membrane proteins or ion channels),
  • learned-model–assisted protein design workflows (e.g., structure prediction, inverse folding/sequence design, protein language-model–based sequence scoring, and generative sequence/structure proposal tools),
  • generative or library-based design and screening strategies (incl. directed evolution),
  • molecular biology for rapid design–build–test cycles (cloning, construct design, expression optimization),
  • metagenomic mining/discovery pipelines and annotation,
  • quantitative functional screening (microplate assays and/or electrophysiology/imaging readouts).
  • Strong motivation to develop and refine methods, primarily in silico, with a light but competent experimental component.
  • Highly organized and precise; comfortable managing multiple design iterations with rigorous documentation and version control.
  • Solid programming and data-analysis skills (e.g., Python) and experience working with structural biology and protein-design software/toolchains (e.g., Rosetta; structure-prediction workflows such as AlphaFold-derived or equivalent; inverse-folding/sequence-design and generative design tools; MD/analysis toolchains).
  • Practical competence with mammalian cell culture and sterile technique; familiarity with BSL1/BSL2 environments.
  • Evidence of impact in protein design (e.g., first-author work, open-source contributions, released methods, or demonstrated engineered-function outcomes).
Créer une alerte emploi pour cette recherche

Research Associate, Computational Ion Channel Design, Synthetic and Structural Biology 100% • Basel, CH

Offres similaires

Clinical Scientist

headcountBasel,Switzerland
Quick Apply

We are supporting a pharma company in Basel that is looking for a Clinical Scientist to join their team on a 12 month contract.The role will focus primarily on clinical trial data cleaning and data...Voir plus

QC Lab Technician (m/w/d), 100%

EDP Personalberatung GmbHRaum Liestal

QC #GMP #Analytik #Schichtmodell6/4 #Topjob #YourNewJob.Laborant/in für die Abteilung QC.QC Lab Technician (m/w/d), 100%.Ein vielseitiges und anspruchsvolles Aufgabengebiet mit hoher Eigenverantwor...Voir plus

 • Offre sponsorisée

System Engineer (w/m) 100%

yellowsharkReinach BL, BL, Switzerland, CH

Diese Position richtet sich an engagierte Persönlichkeiten mit fundierter IT-Erfahrung, die kundenfokussiert denken und Lust auf zukunftsorientierte Technologien haben.Planung und Umsetzung hybride...Voir plus

 • Offre sponsorisée

Teamleiter/in Forschung & Entwicklung

Berlac AGSissach, CH

Die zur Berlac Group gehörende Berlac AG ist seit bald 100 Jahren auf die innovative Entwicklung und den agilen Vertrieb von hochwertigen Strassen- und Flächenmarkierungen sowie Spezial- und Effekt...Voir plus

 • Offre sponsorisée

Internship in IPV Development

Sentec AGTherwil, CH

As an IPV Technology Intern, you will work closely with our experienced professionals to learn about, contribute to, and explore intrapulmonary percussive ventilation technology.You will be exposed...Voir plus

 • Offre sponsorisée

Lab Associate – Cellular, Functional & Soluble Biomarkers (m/w/d) (LSW) – Basel

Manpower SwitzerlandBasel

MANPOWER AG – Ihre Karriere im Fokus!.Mit unseren drei Marken – Manpower, Experis und Talent Solutions – unterstützen wir Unternehmen verschiedenster Branchen bei der Personalbeschaffung.Seit 75 Ja...Voir plus

 • Offre sponsorisée

Requirement Engineer Integration Platform

Centris AGSolothurn, CH

Erstellen von fachlichen Spezifikationen und Dokumentationen auf Basis der Business Requirements.Durchführung von Workshops und Interviews mit Kunden, Fachabteilungen sowie internen Stakeholdern zu...Voir plus

 • Offre sponsorisée

AI Project Manager- Drug discovery

Gi Life Sciences BaselBasel, CH

Für einen Kunden in Basel suchen wir eine motivierte Peron für die Stelle.AI Project Manager- Drug discovery.Lead the end-to-end lifecycle of AI projects and programs, from ideation and planning th...Voir plus

 • Offre sponsorisée

Senior Scientist, Comparative Digital Pathology, Computational Biology and Medicine

WhatJobsBasel, Basel-Stadt, Schweiz

At Roche you can show up as yourself, embraced for the unique qualities you bring.Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted ...Voir plus

 • Offre sponsorisée

Head of Research & Development Services

Omya (Schweiz) AGEgerkingen, CH

Head of Research & Development Services.Omya is seeking a visionary Head of Research & Development Services to lead a global team of scientific experts and drive innovation across disciplines such ...Voir plus

 • Offre sponsorisée

Senior Analytical Project Leader (Sr. APL), 100% (m/w/d)

Corden Pharma Switzerland LLCLiestal, CH

CordenPharma ist ein führender Anbieter für die Entwicklung und Herstellung von pharmazeutischen Wirkstoffen (APIs), Hilfsstoffen, Fertigarzneimitteln und Verpackungsaktivitäten mit mehr als Mitarb...Voir plus

 • Offre sponsorisée

Scientist imaging and physical characterization

Solvias AGKaiseraugst, CH

Ready to take on the challenge of fascinating analytics in a great team?.As a Scientist specializing in microscopy imaging and physical characterization, you will play a crucial role in developing ...Voir plus

 • Offre sponsorisée

Quantum Founders in Life Sciences (Venture Building with QAI Ventures)

QAI Ventures AGArlesheim, Basel-Landschaft, Switzerland
Quick Apply

VC-backed venture with QAI Ventures.Founders with a PhD or Postdoc.Life Sciences & Healthcare (Pharma, Biotech, Healthcare),.The venture-building process is anchored in.This opportunity starts with...Voir plus

Drug Product MSAT Technology Deployment Steward

Elan Personal AGBasel, CH

Drug Product MSAT Technology Deployment Steward.Roche Switzerland bridges the gap between pharmaceuticals and diagnostics.Important research and development functions are located here.Hoffmann-La R...Voir plus

 • Offre sponsorisée

Internship Sensor Development

Sentec AGTherwil, CH

Work hands-on with our transcutaneous monitoring system.Building Sensor Prototypes and test their performance.Design experiments together with the team to answer key questions in product developmen...Voir plus

 • Offre sponsorisée

Staff Quantum Physicist - System Operations

Oxford IonicsBasel, BS, CH
Quick Apply

Quantum is now, and it's built here.Using our world-leading trapped-ion technology, we’re building the most powerful, accurate and reliable quantum systems to tackle problems that today’s supercomp...Voir plus

Senior Analytical Project Leader, 100%

Corden Pharma Switzerland LLCLiestal, CH

Senior Analytical Project Leader (Sr.CordenPharma ist ein führender Anbieter für die Entwicklung und Herstellung von pharmazeutischen Wirkstoffen (APIs), Hilfsstoffen, Fertigarzneimitteln und Verpa...Voir plus

 • Offre sponsorisée

Teamleiter/in Forschung & Entwicklung (w/m/d, 100%)

Berlac AGSissach, CH

Zu Ihrem Aufgabengebiet zählen.Kollaborative Führung und Koordination des F&E-Teams (3 Personen).Entwicklungen unterschiedlicher Lacksysteme: lösemittelhaltig, wässrig sowie auch UV-härtend für ver...Voir plus