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Research Specialist in Microscopy and Spatial Transcriptomics
Research Specialist in Microscopy and Spatial TranscriptomicsThe Biozentrum, University of Basel • Basel, CH
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Research Specialist in Microscopy and Spatial Transcriptomics

Research Specialist in Microscopy and Spatial Transcriptomics

The Biozentrum, University of Basel • Basel, CH
Il y a plus de 30 jours
Description de poste

Your position

This position will establish and operate advanced imaging and spatial transcriptomics pipelines for high-resolution molecular profiling in intact tissues. The specialist will develop and apply methods enabling large-volume processing-such as whole brain spatial transcriptomics-and integrate techniques including expansion microscopy and multiplexed FISH.

Your responsibilities
  • Operate, maintain, and expand commercial and custom-built systems for spatial transcriptomics and microfluidic tissue processing.
  • Develop protocols for volumetric molecular imaging, including expansion microscopy and multiplexed in situ hybridization workflows.
  • Establish whole-mount and thick-section spatial transcriptomics pipelines, ensuring tissue integrity, reproducible labeling, and high-content imaging compatibility.
  • Build or adapt instrumentation required for large-volume sample processing and imaging.
  • Coordinate with researchers, image analysts and data specialists to generate robust, standardized whole-brain datasets.
  • Train and support researchers in applying facility methods to their own samples.
  • Contribute to development of facility infrastructure for long-term whole-tissue profiling.

Your profile

  • PhD in neuroscience, bioengineering, biophysics, molecular biology, or related discipline.
  • Expertise in advanced microscopy (light-sheet, confocal, multiphoton).
  • Experience with spatial transcriptomics, expansion microscopy, or multiplexed FISH.
  • Skills in instrumentation, microfluidics, or custom optical systems.
  • Experience with tissue clearing or large fixed tissue preparations advantageous.
  • Strong communication skills, interest in interdisciplinary work, and ability to train students and postdocs.
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Research Specialist in Microscopy and Spatial Transcriptomics • Basel, CH

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