Principal Software Engineer (Python AI Systems) | EU

About the Hiring Process When you apply, our AI-powered matching platform considers you not only for this opportunity, but also for other relevant roles across our network, so one application can unlock multiple career opportunities. We only work with real companies hiring for live positions. Every opportunity on our platform is an active search. If there's a strong match, we'll guide you through the process. If not, we won't ignore you. About the Company Our client is an early-stage healthcare AI startup building autonomous AI clinicians capable of transforming how healthcare is delivered. Their mission is ambitious: create AI systems that can automate clinical workflows, assist healthcare professionals, and ultimately make high-quality healthcare accessible to everyone. Working at the intersection of AI, distributed systems, and healthcare, they're building production-grade technology designed to solve one of humanity's most important challenges. Location: Europe (Remote) Employment Type: Full-time (Permanent or B2B) Level: Principal Individual Contributor Work Authorization: Must be based within the European Union (hired via Deel where applicable) About the Role We're looking for a Principal Software Engineer to design and build the core infrastructure powering autonomous AI clinicians. This is a highly hands-on engineering role focused on building large-scale distributed systems, AI agents, secure healthcare infrastructure, and production-grade backend platforms. You'll work directly with founders, hospitals, and healthcare providers to solve complex technical problems that have real-world impact. If you're a builder who thrives in ambiguity, enjoys solving difficult engineering challenges, and wants to shape the future of AI-powered healthcare, we'd love to hear from you. What You'll Do AI Platform Engineering; Architect and build AI agent systems for healthcare applications Design scalable distributed backend services Develop secure healthcare infrastructure handling sensitive clinical data Build low-latency communication systems supporting voice and video workflows Production Engineering; Build scalable Python services powering enterprise healthcare platforms Design APIs, orchestration systems, and backend infrastructure Optimize system performance, scalability, and reliability Improve deployment, monitoring, and operational excellence AI Systems; Build production systems around LLMs, AI agents, and reinforcement learning Design agent orchestration frameworks Integrate AI capabilities into real-world healthcare workflows Continuously improve system accuracy and operational performance Technical Leadership; Translate ambiguous product challenges into scalable engineering solutions Partner directly with founders and product teams Help shape technical architecture and engineering standards Mentor engineers through technical leadership and example What We're Looking For Must Have; 5+ years building complex production software systems Strong Python engineering experience Experience designing scalable distributed systems Track record of building production-grade backend platforms Experience turning ambiguous requirements into reliable solutions Strong system design and architecture skills Startup or high-growth company experience High ownership and strong problem-solving mindset Excellent communication skills Based in Europe Nice to Have; Healthcare technology experience AI, LLM, or Agentic AI experience Reinforcement Learning Cloud infrastructure (AWS, GCP, Azure) Enterprise software experience Open-source contributions Background in Mathematics, Computer Science, or Physics Experience building products from zero to production What We Offer €100,000–€200,000 salary Meaningful equity package Fully remote across Europe Flexible employment (Permanent or B2B) Opportunity to work directly with founders High ownership from day one Small, elite engineering team Mission-driven work solving one of healthcare's biggest challenges Opportunity to build technology with global impact If you're excited about building production AI systems that could redefine the future of healthcare, we'd love to hear from you...