Research Associate, Cell Therapy Translational Research
Research Associate, Cell Therapy Translational Research
The Biozentrum, University of Basel • Basel, CH
Vor 25 Tagen
Stellenbeschreibung
Your position
Hands-on development of a novel stem cell therapy for corneal regeneration
Establish, optimize, and routinely perform stem cell culture, expansion, and characterization
Directly execute ex vivo genome editing experiments in primary stem cells using base and prime editing
Perform functional in vitro assays to assess stem cell identity, differentiation, and regenerative potential
Generate and analyze single-cell RNA-seq and spatial transcriptomics data from primary tissues, cultured cells, and edited cells
Independently design, perform, document, and interpret experiments in a reproducible manner
Prepare and adapt laboratory protocols for technology transfer to a GMP facility
Work closely with technical staff and assist in supervising research assistants, while remaining experimentally active
Contribute experimentally to translational documentation, regulatory preparation, and clinical protocol development
Develop and experimentally validate biomarkers for stem cell engraftment and function in human samples
Present experimental results internally, to collaborators, and at international conferences
Mentor junior lab members through direct experimental guidance and training
Your profile
PhD in Biology, Stem Cell Biology, Molecular Medicine, or a related field
Strong hands-on experience with cell-based or stem cell therapies (e.g. epithelial stem cells, CAR T cells, iPSC-derived products)
Demonstrated ability to work independently at the bench with primary human cells
Practical experience with CRISPR-based genome engineering; experience with base or prime editing is highly desirable
Solid background in cell culture, molecular biology, and in vitro functional assays
Experience with single-cell RNA sequencing and / or spatial transcriptomics workflows
Experience working under BSL-2 conditions
Prior exposure to GMP environments or technology transfer is an advantage but not required
Excellent organizational skills and strong attention to experimental detail
Clear scientific communication skills and a collaborative working style
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Research Associate Cell Therapy Translational Research • Basel, CH
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