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Research Associate, Cell Therapy Translational Research
Research Associate, Cell Therapy Translational ResearchThe Biozentrum, University of Basel • Basel, CH
Research Associate, Cell Therapy Translational Research

Research Associate, Cell Therapy Translational Research

The Biozentrum, University of Basel • Basel, CH
Vor 25 Tagen
Stellenbeschreibung

Your position

  • Hands-on development of a novel stem cell therapy for corneal regeneration
  • Establish, optimize, and routinely perform stem cell culture, expansion, and characterization
  • Directly execute ex vivo genome editing experiments in primary stem cells using base and prime editing
  • Perform functional in vitro assays to assess stem cell identity, differentiation, and regenerative potential
  • Generate and analyze single-cell RNA-seq and spatial transcriptomics data from primary tissues, cultured cells, and edited cells
  • Independently design, perform, document, and interpret experiments in a reproducible manner
  • Prepare and adapt laboratory protocols for technology transfer to a GMP facility
  • Work closely with technical staff and assist in supervising research assistants, while remaining experimentally active
  • Contribute experimentally to translational documentation, regulatory preparation, and clinical protocol development
  • Develop and experimentally validate biomarkers for stem cell engraftment and function in human samples
  • Present experimental results internally, to collaborators, and at international conferences
  • Mentor junior lab members through direct experimental guidance and training

Your profile

  • PhD in Biology, Stem Cell Biology, Molecular Medicine, or a related field
  • Strong hands-on experience with cell-based or stem cell therapies (e.g. epithelial stem cells, CAR T cells, iPSC-derived products)
  • Demonstrated ability to work independently at the bench with primary human cells
  • Practical experience with CRISPR-based genome engineering; experience with base or prime editing is highly desirable
  • Solid background in cell culture, molecular biology, and in vitro functional assays
  • Experience with single-cell RNA sequencing and / or spatial transcriptomics workflows
  • Experience working under BSL-2 conditions
  • Prior exposure to GMP environments or technology transfer is an advantage but not required
  • Excellent organizational skills and strong attention to experimental detail
  • Clear scientific communication skills and a collaborative working style
  • Jobalert für diese Suche erstellen

    Research Associate Cell Therapy Translational Research • Basel, CH

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