Principal Scientist Hematology

CSL's R&D organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we’re building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide.

The Principal Scientist in Translational Research Hematology is responsible for the design, execution, and oversight of translational and non-interventional biomarker studies, with a focus on understanding disease mechanisms, target validation, and biomarker discovery. This role plays a pivotal part in bridging preclinical research and clinical development by applying scientific expertise to support therapeutic area (TA) strategies, particularly in Hematology. The position includes scientific leadership, cross-functional collaboration, especially with Pre-clinical Pharmacology, Clinical Pharmacology, Data Science and Early Clinical Development functions, and strategic input into global research and development initiatives.

Main Responsibilities :

Design, implement, and oversee translational and non-interventional biomarker studies, including protocol development development in the fields of Hematology, data analysis, and quality assurance. ​Contribute to biomarker strategies for toxicology and early clinical studies, by fully leveraging all elements for generation of Integrated Translational Evidence, i.e systematic literature reviews, integration of real-world data / evidence, insights gained from post-hoc studies and from prospective, non-interventional research studies (NIRS).​

Lead and support mechanism of action studies, biomarker discovery and development, and target validation using in vitro, ex vivo, and in vivo models, working closely with the internal Pharmacology Unit and NCD or external partners / vendors to access lab capabilities (e.g., academic institutions, biotech companies).​

Provide scientific and operational guidance to R&D projects across preclinical and clinical phases.​

Represent TR in RPTs.​

Represent Translational Research in global cross-functional teams, such as PSTs, NCETs and BETs, working closely with Pre-clinical Pharmacology, Clinical Bioanalytics and Biomarkers, Clinical Pharmacology, Data Science and Early Clinical Development functions.​

Contribute to regulatory submissions, investigator brochures, and scientific publications.​

Supervise and mentor research scientists (e.g. from internal Pharmacology Units ), ensuring delivery of TA-aligned research packages.​

Maintain state-of-the-art knowledge through literature review and participation in scientific meetings.​

Support contract negotiations and patent filings in collaboration with legal teams.​

Ensure compliance with quality standards and contribute to the maintenance of the QM system.​

Provide input into strategic planning and due diligence processes for early-phase projects.​

Qualifications and Experience Requirements :

PhD, MD-PhD or equivalent in a relevant discipline (e.g., Biochemistry, Cell Biology, Immunology, Molecular Biology, Epidemiology), specific expertise in relevant to CSL’s TA Strategies is a prerequisite.​

Minimum of 5 years of relevant experience in industry and / or academia, with a strong track record in translational research.​

Proven expertise in biomarker discovery, non-interventional study design, and translational biology.​

Experience in integrating clinical and scientific data to inform hypothesis generation and clinical development.​

Strong knowledge of epidemiological and statistical methods applied to translational and observational studies.​

Demonstrated leadership and people management skills in a matrixed, cross-functional environment.​

Excellent communication, analytical, and strategic thinking skills.​

Experience in regulatory documentation, scientific writing, and external collaborations.​

Ability to work effectively in multicultural and international teams.​

Are you interested? We are looking forward to receiving your online application.

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