2 PhD positions in Endocrinology (x1 Genetics & Bioinformatics/x1 Genetics)

Contexte

The Centre Hospitalier Universitaire Vaudois (CHUV) is one of the 5 Swiss university hospitals. Through its collaboration with the University of Lausanne - Faculty of Biology and Medicine and the École Polytechnique Fédérale de Lausanne (EPFL), the CHUV plays a leading role in the fields of medical care, medical research and training.

The candidates will work on projects aiming to determine the neuroendocrine basis of human reproduction by combining clinical data, human genetics, bioinformatics and IPS cell-based model systems. The discovery of novel genes involved in congenital hypogonadotropic hypogonadism (CHH) may allow for a better genotype-phenotype correlation, as well as an improvement in precision medicine and genetic counselling. The patients’ mutations present in novel genes identified throughout this project will i) be used to assess their effect on human GnRH neuron biology and ii) increase our understanding of neuroendocrine control of reproduction with potential applications to a broader spectrum of fertility pathologies.

Mission

Through the doctoral thesis:

• You will implement a variety of bioinformatics and genetics applications to high-throughput sequencing data (e.g. WGS, bulk and single cell RNA-seq…)(1, 2)

• You will help discover new genes and pathways involved in the pathogenesis of congenital hypogonadotropic hypogonadism and puberty

• You will compile, evaluate and compare the clinical, genetic, and metabolomics data from our large CHH patients cohort with control cohorts (1, 2)

• You will implement in vitro models of GnRH neuron development using patient-derived IPS cells

Profil

• You have a master’s degree in genetics / bioinformatics / molecular & cellular biology

• You have a previous experience in human genetics, high - throughput data handling, bioinformatics / programming, Stem cell / IPS cells derivation and differentitation

• You have strong organizational skills and ability to work as part of a collaborative, international team

• You are fluent in French, English

Nous offrons

To become an employee of the world-famous University Hospital Center from the Canton of Vaud is an assurance of:

• First-rate social benefits such as a Paternity Leave of 20 days and a Maternity Leave of 4 months (there is also the possibility to obtain a complementary breastfeeding leave of 1 month)
• Regular salary progression adapted to your responsibilities
• 25 days of vacations per year
• A right to at least three days of training per year, by accessing a wide offer of courses not only from the CHUV Training Center but also from external providers
• Possibility to access one of the furnished apartments offered in the surrounding neighborhoods in case of relocation in Switzerland
• Discounts proposed on social and cultural events, goodies and other services, thanks to the “H-Oxygène” association
• Signing up to our Mobility Plan and benefit from different advantages (discounts on public transportation, promotion of “Mobility” car fleet and discounts on electric bikes)
• Being able to enjoy our high-quality corporate restaurants, located in every hospital building, with employees’ discount.