Scientist Biology

Band

Level 3

Job Description Summary

Senior Scientist I Oncology Translational Research

The Oncology Translational Research (OTR) Department at Novartis Biomedical Research is a global laboratory-based research group supporting the development of novel therapeutics in the Novartis Biomedical Research Oncology Disease Area.

Within OTR the Oncology Pathology and Biomarkers (OPB) team leverages tissue- cell- and soluble proteinbased assays to profile target epidemiology and biology elucidate drug mechanisms of action and define response / resistance biomarkers from early target discovery through Phase 3 clinical development. OPB is seeking a motivated inquisitive scientist to design and execute imaging-driven experiments that inform clinical biomarker strategies and accelerate Novartis Oncology drug candidates.

Job Description

The successful candidate will generate rigorous high-quality data to propel translational research programs. By applying automated immunohistochemistry immunofluorescence and quantitative image analysis they will help identify molecular predictors of response to cancer therapies mechanisms of resistance or persistence under treatment and opportunities for combination strategies.

Working closely with the lab head and team members the candidate will flexibly contribute to both local and global projects and proactively share expertise across groups spanning the full Oncology portfolio including radioligand therapeutics (RLT).

Key responsibilities :

Deliver highquality data to impact drug discovery and projects in clinical development

Design and conduct experiments and procedures requiring scientific and technical knowledge of immunohistochemistry and immunofluorescence

Devise new techniques around tissue-based biomarkers to advance drug development and early discovery programs

Supervise the development of multiplex IHC FIHC and ISH assays

Conduct in-depth image analysis of whole slide images using established platforms

Consolidate report data and present in context as needed

Efficiently manage and maintain a functional laboratory technical equipment and reagents

Stay updated on the latest developments and trends in the field of Oncology and Radioligand Therapy

Role Requirements :

MSc or BSc or qualified Lab Technician in Biological Sciences or other relevant discipline with minimum 2 years of histology laboratory experience

Advanced / Fluent English oral and written

Must have experience developing singleplex and multiplex immunohistochemistry and immunofluorescence tissue-based assays

Proven experience with advanced image analysis using various software tools including HALO

Experience working with cross-functional teams and demonstrated ability to independently drive projects in a matrixed environment

Knowledge of cancer signaling / biology is preferred background in radioligand development and autoradiography is a plus

Excellent organizational and communication skills

Languages : English.

Novartis is committed to working with and providing reasonable accommodation to all individuals. If because of a medical condition or disability you need a reasonable accommodation for any part of the recruitment process or in order to receive more detailed information about the essential functions of a position please send an e-mail to and let us know the nature of your request and your contact information. Please include the job requisition number in your message

Skills Desired

Analytical Skill Analytical Skill Analytical Thinking Chemical Biology Chemistry Clinical Research Clinical Trials Collaboration Communication Skills Curious Mindset Data Data Analysis Design Of Experiments Detail-Oriented Diversity & Inclusion Drug Discovery Ethics Gene Therapy Immunology Laboratory Lifesciences Machine Learning (ML) Mammalian Cell Culture Medical Research Molecular Biology 11 more

Key Skills

Laboratory Experience,Immunoassays,Machine Learning,Biochemistry,Assays,Research Experience,Spectroscopy,Research & Development,cGMP,Cell Culture,Molecular Biology,Data Analysis Skills

Employment Type : Full-Time

Experience : years

Vacancy : 1