Lab Associate for Cellular m functional and soluble Biomarkers

Lab Associate for Cellular m functional and soluble Biomarkers (m / f / d)- : Biomarker / Flow cytometry / ELISA / GxP / English

Project : For our client based in Basel, we are looking for a Lab Associate for Cellular m functional and soluble Biomarkers.

Background :

Pharmaceutical Research and Early Development At Clients Pharmaceutical Research and Early Development (pRED), our mission is to transform cutting-edge science into transformative medicines for patients, addressing some of the world's most challenging unmet healthcare needs. We foster a culture defined by curiosity, responsibility, and humility, empowering our talented people to accelerate extraordinary, life-changing innovation. pRED's Pharmaceutical Sciences group enables discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines. PS supports discovery and development across the whole value chain from target assessment to on-market. This position is situated within the Bioanalytics and Biomarkers (BioAM) Chapter of the Pharmaceutical Sciences (PS) function. Our chapter is responsible for developing Bioanalytical and Biomarker methods and implementing them in Roche clinical studies to help guide drug development. We collaborate closely with different disease therapeutic areas and other functions to convert hypotheses into innovative therapeutics.

The Perfect Candidate :

The ideal candidate is a proactive scientist with a Master's or Bachelor's degree and at least two years of industry experience in developing complex cellular and protein biomarker assays. They possess deep technical expertise in platforms like flow cytometry and ligand-binding assays (eg, ELISA, MSD), coupled with a strong understanding of GxP regulations for clinical trial support. Beyond technical skill, this individual thrives in a matrixed environment, balancing hands-on lab work with the strategic management of external CRO partners to deliver high-quality, patient-focused data.

Tasks & Responsibilities :

• With our deep expertise in immunology, technology, and applied cellular and protein biomarker measurement, we shape and enable the implementation of innovative clinical biomarker strategies. We ensure the delivery of high-quality, decision-enabling data by leading method development, validation, data analysis, and laboratory selection. Our team continuously evaluates and integrates cutting-edge technologies, always striving to apply the most effective approaches to address key biological questions and advance patient-focused science.
• As an Associate in Cellular and Functional Biomarkers, you will be an integral part of this mission - designing, developing, and transferring biomarker assays that support Roche clinical trials. You will lead in-house assay development, support method transfers to external CRO partners, and ensure the generation of robust, high-quality biomarker data from method development through to clinical sample analysis.
• Self-driven planning, development, troubleshooting and critical analysis of results
• of analytical methods for complex cellular, functional, and soluble protein biomarkers supporting preclinical and clinical drug development, in full compliance with regulatory and GxP requirements. Design and execute experimental protocols, generate, analyze, troubleshoot, interpret data, and deliver high-quality reports aligned with project timelines.
• Support method transfer and implementation with external partners, ensuring proper documentation and efficient troubleshooting.
• Seek, evaluate and introduce novel technologies to enhance biomarker strategies and expand their application across therapeutic areas.
• Collaborate with internal / external stakeholders to ensure data integrity, technical and scientific rigor, and timely resolution of technical challenges.
• Presentations of activities and results on internal / external meetings.
• Contribute to a culture of innovation, continuous improvement, and compliance with Safety, Security, Health, and Environmental (SHE) standards.

Must Haves :

Cellular and functional assays : Flow cytometry, pFlow, ELISpot / FluoroSpot, HTRF. -Ligand-binding assays : ELISA, ELLA, Simoa, Elecsys, MSD. -Hands-on experience in technology implementation, optimization, and troubleshooting of bioanalytical / biomarker methods.