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PhD position on "On-Chip Separation of Proteins for Single-Cell Proteome Profiling"
Institute for Biomedical Engineering (D-ITET)ZurichVor 30+ Tagen
StellenbeschreibungSolid working knowledge in either on-chip protein separation, microfluidics or nanofluidic. Hands-on experience with protein samples. Working experience in cell labs is valuable. Familiarity with data analysis using bioinformatic tools is highly valuable. Independent personality, self-driven, creative, solution-oriented, open-minded, team-player & collaborative.
Job description
- You will be developing a platform for the detection of protein production and secretion in single cells. An example of application is to study antibody secretion in immune cells upon their activation
- You will be optimizing recently established scanning nanopore microscope for specific detection of proteins in complex physiological solutions, addressing these open research challenges :
- Specificity of the sensor towards selected proteins : Enhancing the contrast for specific proteins
- Data analysis : Improving data analysis approaches for capturing more information from each individual protein
- Sampling from single cells : Developing methods for better sampling from individual cells, and handling of small volume samples
- You will be collaborating with colleagues from the machine learning domain to improve data analysis
- You will be responsible for project meetings, reporting, scientific publications, and conference / seminar presentations
- You will supervise master / bachelor students
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