Head of Computational Chemistry

Principal Scientist Head of Computational Chemistry Argau Canton Switzerland Permanent job

The company

The company is a rapidly growing biotech company focusing on solving structures of membrane protein drug targets (e.g. GPCRs ion-channels and transporters) for the discovery and optimization of next-generation medicines. Based on a unique platform for membrane protein expression purification and engineering and preferential access to synchrotron and free electron laser beamlines for X-ray analysis and cryo-EM facilities they characterize the interaction of small molecules and biotherapeutics with drug targets in time to impact the discovery of novel therapeutics.

Key tasks and responsibilities

• Utilize modern molecular modelling methods to support different stages of R&D programs.
• Collaborate effectively with other functions to advance research discovery projects expeditiously from early target assessment to hit-to-lead and lead optimization.
• Design lead and drive computational studies on projects throughout the several discovery phases and ensure execution on agreed deliverables.
• Set the vision and strategy for computational chemistry.
• Manage data warehousing for lead discovery projects using CDD Vault to facilitate secure and efficient data management and collaboration.
• Collaborate with external partners on joint drug discovery projects.
• Present plans and results internally including at board level and externally at conferences.
• Keep up to date with the latest scientific advances and trends in drug discovery to deliver the next-generation therapies.

Your qualification

• MSc/PhD in a relevant scientific discipline (Pharmaceutical Sciences Chemistry Computational Chemistry) with a solid foundation in molecular modelling built in a pharma/biotech/CRO setting.
• Expert knowledge in CADD software packages and modern molecular modelling techniques.
• Sound knowledge in cutting-edge cheminformatic tools AI/ML-enabled technologies and in silico drug design including both structure- and ligand-based methodologies.
• Passion for drug discovery with a deep understanding of membrane protein drug targets (e.g. GPCRs ion-channels and transporters).
• Mastery of all the theoretical and practical principles of medicinal chemistry and drug design.
• Broad knowledge of biophysical biochemical and cell-based assays used in the early stages of the drug discovery process.
• In depth understanding of multi-parameter optimization and ability to integrate disease biology ADME/DMPK and toxicology data to solve complex drug discovery problems.
• Excellent leadership management organizational and team-working skills and a talent to deliver project milestones within the expected time frame.
• Demonstrated track record of scientific publications.

Benefits

• You will be working for an innovative company aiming to discover new generation medic
• You will be working with state-of-art technologies
• You will be working in a supportive and dynamic team
• Share options bonus

If you are interested please send a CV.

It is essential that applicants hold entitlement to work in Switzerland. Please quote job reference 156433 in all correspondence.
Employment Type : Full Time
Experience: years
Vacancy: 1