Research Specialist in Microscopy and Spatial Transcriptomics

Your position

This position will establish and operate advanced imaging and spatial transcriptomics pipelines for high-resolution molecular profiling in intact tissues. The specialist will develop and apply methods enabling large-volume processing-such as whole brain spatial transcriptomics-and integrate techniques including expansion microscopy and multiplexed FISH.

Your responsibilities

• Operate, maintain, and expand commercial and custom-built systems for spatial transcriptomics and microfluidic tissue processing.
• Develop protocols for volumetric molecular imaging, including expansion microscopy and multiplexed in situ hybridization workflows.
• Establish whole-mount and thick-section spatial transcriptomics pipelines, ensuring tissue integrity, reproducible labeling, and high-content imaging compatibility.
• Build or adapt instrumentation required for large-volume sample processing and imaging.
• Coordinate with researchers, image analysts and data specialists to generate robust, standardized whole-brain datasets.
• Train and support researchers in applying facility methods to their own samples.
• Contribute to development of facility infrastructure for long-term whole-tissue profiling.

Your profile

• PhD in neuroscience, bioengineering, biophysics, molecular biology, or related discipline.
• Expertise in advanced microscopy (light-sheet, confocal, multiphoton).
• Experience with spatial transcriptomics, expansion microscopy, or multiplexed FISH.
• Skills in instrumentation, microfluidics, or custom optical systems.
• Experience with tissue clearing or large fixed tissue preparations advantageous.
• Strong communication skills, interest in interdisciplinary work, and ability to train students and postdocs.