Research Associate, Computational Ion Channel Design, Synthetic and Structural Biology (100)

The Institute of Molecular and Clinical Ophthalmology Basel (IOB) seeks a highly motivated Research Associate. IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding vision and its diseases and develop new therapies for vision loss. It is a place where your expertise will be valued your abilities challenged and your knowledge expanded.

We are recruiting a Research Associate in computational ion channel and membrane-protein design (protein design structural and synthetic biology). In this role you will drive an end-to-end designbuildtest cycle : computationally design engineered ion channels (e.g. light-responsive membrane proteins) translate designs into expression constructs and validate function in mammalian systemsin collaboration with colleagues performing quantitative assays (with access to high-throughput electrophysiology and advanced imaging). The position combines modern structure-based and generative design approaches with hands-on experimental execution (mammalian cell culture transfection / transduction expression optimization and protein / function characterization).

Your responsibilities

• Own the computational and structural design cycle for ion channels and light-sensitive membrane proteins (concept design hypotheses in silico screening selection of candidates for testing) in close interaction with experimental and translational collaborators.
• Define clear design objectives and success criteria and translate designs into practical construct and assay plans.
• Develop and apply learned-modelassisted protein design workflows (structure prediction inverse folding / sequence design sequence scoring and generative proposal methods) and integrate them with experimental feedback across iterative design cycles.
• Execute a targeted experimental validation workflow (limited hands-on bench work) : some routine mammalian cell culture DNA cloning / construct handling as needed transfection / transduction and small-scale expression testing in HEK / CHO (or equivalent).
• Coordinate and interpret functional readouts generated with the team (e.g. electrophysiology imaging biochemical assays) using results to iterate designs.
• Communicate progress and results clearly in internal updates written documentation and project meetings; contribute to conference presentations and manuscripts as appropriate.
• Maintain accurate records and effective day-to-day communication with your supervisor and collaborators.

Requirements

computational / structure-based protein design (especially membrane proteins or ion channels)

We offer

Application / Contact

Interested candidates should submit their applications online via the recruitment platform. Please include a motivation letter and your Curriculum Vitae. For further information please visit our website or contact Dr. Guilherme Testa-Silva ()

Required Experience :

IC

Key Skills

Stress Analysis,Structural Design,Structural Engineering,Structural Steel,Mathcad,Engineering designs,Aerospace,CAD,Construction Documents,Autocad,Engineering Drawings,Structural Analysis,Layouts,Catia,ANSYs

Employment Type : Full-Time

Experience : years

Vacancy : 1